Validation

=**Validation**=


 * Definition1:** The identification of the strengths and weaknesses of the study to determine if the limitations and weaknesses invalidate the findings and conclusions.
 * Source:** MacLachlan LW. General considerations about the utilization of research by clinicians. In: Fraelich Phillips LR, editor. A clinician's guide to the critique and utilization of nursing research. Norwalk, CT: Appleton-Centruy-Crofts, 1986: 381-405.
 * Focus:** Clinical research

=External Validation= Journal of Clinical Epidemiology 2001; 54: 774–781. **Definition 2:** External validation aims to address the accuracy of a model in patients from a different but plausibly related population, which may be defined as a selected study population representing the underlying disease domain. **Source:** Bleeker SE, Moll HA, Steyerberg EW. External validation is necessary in prediction research: A clinical example. Journal of Clinical Epidemiology 2003; 56: 826–832. **Focus:** Clinical Research **Date added:** 07/2/2011
 * Definition 1:** Internal validation refers to the performance in patients from a similar population as where the sample originated from. Internal validation is in contrast to external validation, where various differences may exist between the populations used to develop and test the model.
 * Source:** Steyerberg et al. Internal validation of predictive models: Efficiency of some procedures for logistic regression analysis.
 * Focus:** Clinical Research
 * Date added:** 07/2/2011


 * Definition 2:** The process in which a team of people from outside an institution comment on the accuracy and completeness of the Institutional Self-study; part of the Evaluation Process Audit.
 * Source:** __ [|www.scoea.bc.ca/glossary2001.htm] __
 * Focus:** n/a
 * Date added:** 07/2/2011

=Internal Validation= Journal of Clinical Epidemiology 2001; 54: 774–781.
 * Definition 1:** Internal validation refers to the performance in patients from a similar population as where the sample originated from.
 * Source:** Steyerberg et al. Internal validation of predictive models: Efficiency of some procedures for logistic regression analysis.
 * Focus:** Clinical Research
 * Date added:** 07/2/2011
 * Definition 2:** Internal validation generally refers to validation procedures solely based on the study dataset.
 * Source:** Cheng C. **I**nternal validation inferences of significant genomic features in genome-wide screening. Comput Stat Data Anal. 2009; 53(3): 788–800.
 * Focus:** Biostatistics
 * Date added:** 07/31/2011